Wissenschaftliche Preisträger 2019

Anlässlich der 48. Jahrestagung der Deutschen Gesellschaft für Angiologie in Leipzig ehrte die DGA erneut Wissenschaftler für ihre herausragenden Leistungen auf dem Gebiet der Angiologie.

Promotionspreis für Dr. Lisa Boschek, Universitätsklinik Düsseldorf

“Effects of dietary anthocyanins on vascular function“

Background and hypothesis: Anthocyanins are dietary polyphenols present in fruits and vegetables such as blueberries and grapes. Epidemiological studies indicate that there is an inverse association between increased intake of anthocyanin-rich foods and cardiovascular risk. The overall hypothesis of the present work was that anthocyanin consumption can improve vascular function in postmenopausal women. Methods: Two clinical studies were performed. The first study was a randomized double-blind six-arm clinical intervention trial to test the dose response of pure anthocyanins on endothelial function in healthy young men (n = 10). Endothelial function was determined by flow-mediated vasodilation (FMD) along with measurements of blood pressure and anthocyanin metabolites in blood before (0h) and at 2 and 6 hours after the ingestion of capsules containing 0 (control), 80, 160, 240, 320, and 480 mg pure anthocyanins. The metabolites of the anthocyanins were measured in blood using a validated UPLCQ- TOF MS method. The second study was a randomized, double-blind controlled trial to test the acute and chronic effects of pure anthocyanins in healthy postmenopausal women (n = 22). The volunteers received either 160 mg of pure anthocyanins or placebo capsules without anthocyanins bi-daily over one month. The measurements were performed at before (0 h) and at 2 h after intake of the capsules in the morning of the first study day and at 1 month. The primary endpoint was FMD. Secondary endpoints were blood pressure and pulse wave velocity. Results: Anthocyanin intake led to a dose-dependent increase in FMD at 2 and 6 h in healthy young males with significant increases (Δ: 1.1–1.3 %) after intake of ≥ 160 mg pure anthocyanins. Fifty anthocyanin metabolites were identified in plasma. A correlation analysis showed significant correlations between FMD changes and ferulic acid 4-O-sulfate and homovanillic acid at 2 h post-ingestion and dihydro ferulic acid 4-O-sulfate at 6 h post-ingestion. However, anthocyanins failed to exert significant effects on FMD or any of the vascular measurements in postmenopausal women. The baseline polyphenol intake was low in the young males, it was significantly higher in the postmenopausal women. Conclusion: While anthocyanins can acutely and dosedependently increase vascular function healthy young men with low baseline polyphenol intake, these compounds did not affect vascular function in healthy postmenopausal women with a higher baseline polyphenol consumption. Further work is necessary to delineate the contribution of age, sex, and background polyphenol intake on the biological efficacy of anthocyanidins.
Parts of this thesis have been published: Circulating Anthocyanin Metabolites Mediate Vascular Benefits of Blueberries: Insights From Randomized Controlled Trials, Metabolomics, and Nutrigenomics. Rodriguez-Mateos A, Istas G, Boschek L, Feliciano RP, Mills CE, Boby C, et al. J Gerontol A Biol Sci Med Sci. 2019 Jun 18;74(7):967–76. doi: 10.1093/gerona/glz047.


Promotionsstipendium für Charline Wolf, Universitätsklinikum Dresden

Charline Henrike Wolf vom Universitätsklinikum Dresden erhielt das von der DGA vergebene Promotionsstipendium für ihr Dissertationsvorhaben. Mit dem Promotionsstipendium wird einem/r Doktoranden/in ein Freisemester für die Arbeit an der Dissertation ermöglicht.

,,Prospektive Studie zur duplexsonographischen Diagnostik der chronisch venösen Insuffizienz – Messung der Venendiameter und der Venenklappenfunktion bei unterschiedlicher diagnostischer Lagerung des Patienten mithilfe eines Kipptisches"

Zur Diagnostik einer chronisch venösen Insuffizienz sollen, nach aktuellen Leitlinien, Patienten duplexsonographisch im Stehen untersucht werden. Im klinischen Alltag wird dieser Empfehlung aus verschiedenen Intentionen nicht immer nachgegangen. So werden Patienten, bei denen beispielsweise altersbedingt eine Untersuchung im Stehen kaum möglich ist, auch oft im Liegen untersucht. Deshalb soll mithilfe meiner Studie festgestellt werden, ob eine Standardisierung bezüglich der Lagerung des Patienten zu einer optimalen Diagnostik mit konsekutiver Therapieentscheidung erforderlich ist.
Ziel der Studie ist es, mögliche Abhängigkeiten der Venendiameter und der Venenklappenfunktion von der Lagerung des Patienten auf einem Kipptisch bei duplexsonographischer Untersuchung der betroffenen Venen zu detektieren. Dazu sollen 30 Patienten, die aufgrund ihrer chronischen Veneninsuffizienz eine ambulante Lasertherapie der Vena saphena magna erhalten, untersucht werden. Zunächst werden die Patienten zu möglichen Risikofaktoren für die Entwicklung einer chronisch venösen Insuffizienz wie Vorerkrankungen, Berufsanamnese, vorangegangene Operationen, Traumata der unteren Extremitäten, Schwangerschaften oder einer tiefen Venenthrombose befragt.
Die Veneninsuffizienz wird mithilfe des Venous Clinical Severity Scores (VCSS) in ihrem Ausmaß charakterisiert und mit der anschließenden Lichtreflexionsrheographie objektiv bestätigt. Den Hauptteil der Untersuchung nimmt die duplexsonographische Untersuchung der Beinvenen im Liegen (0°), auf dem Kipptisch bei 15°, 30° und 70° und abschließend die Diagnostik im Stehen (90°) ein. Vermessen in ihrem Diameter und auf einen potenziellen Reflux werden im oberflächlichen System die Vena saphena magna und die Vena saphena accessoria anterior, im tiefen System die Vena femoralis superficialis über den gesamten Verlauf.
Nicht an der Studie teilnehmen dürfen Patienten mit einer akuten tiefen Beinvenenthrombose, einem postthrombotischen Syndrom, einer pAVK > Stadium 2 nach Fontaine sowie bei Minderjährigkeit.

Young Investigator Award geht an Henrike Barenbrock, Universitätsklinikum Münster

Mit dem YIA wird die beste Abstract-Einreichung eines jungen Wissenschaftlers unter 35 Jahren ausgezeichnet. Bei der Jahrestagung in Leipzig zeichnete die Jury die Arbeit von Henrike Barenbrock vom Universitätsklinikum Münster aus.

,,Sex related differences in Risk Factors and Outcome after Endovascular Revascluarization in Patients with peripheral artery disease“

Background: Risk profiles and outcome after endovascular revascularization (EVR) may differ between male and female sex. The aim of the study is to identify differences in cardiovascular risk factors between men and women with peripheral artery disease (PAD) and to analyse their impact on the outcome of EVR. Methods: The study included all PAD patients who received EVR at the Division of Vascular Medicine, Cardiol. University Hospital Münster from 2014 to 2016. Detailed data on co-morbidites, behavioural risk factors, clinical parameters of PAD, technical information on EVR, as well as outcome parameters were collected from patient files. Retrospective secondary data analysis was conducted comparing in-hospital, six-months, and twelve-months outcomes between male and female EVR cases. Results: The analysis included in total 1,007 EVR cases referring to 585 patients. The majority of patients was male (73.0 % male vs. 27.0 % female; p < 0.001). Mean age was 68.6 ± 9.6 SD in male vs. 72.7 ± 11.3 SD in females. The most frequent comorbidity comprised arterial hypertension (87.7 % male vs. 85.5 % female), atrial fibrillation (25.2 % male vs. 21.1 % female), chronic heart failure (21.1 % male vs. 22.0 % female) and diabetes mellitus (39.6 % male vs. 34.2 % female), all non-differing by sex. Smoking (59.7 % male vs. 50.0 % female) and dyslipidemia (59.7 % male vs. 49.6 % female) occured significantly more often in male, whereas chronic kidney disease (27.8 % male vs. 35.9 % female) was more frequent in women. Further, prevalence of polyvascular arteriosclerosis was higher in male cases (coronary artery disease 64.2 % male vs. 43.8 % female; p < 0.001; cerebrovascular disease 34.9 % male vs. 24.6 % female; p = 0.002; stroke 15.7%male vs. 10.2%female; p = 0.029; visceral artery disease male 6.8%vs. female 8.6 %; p = 0.328). Critical limb ischemia was present significantly more often in women (42.6 % male vs. 51.3 % female; p = 0.018). Previous amputation was performed in 11.1 % of cases (11.3 % male vs. 10.5%female). Primary technical success rate was equally high between both sexes (successful in 86.1%male vs. 89.2 % female). Complication rate at puncture site was comparable (19.8 % male vs. 20.9 % female; p = 0.706). After twelve months follow-up, PAD stages were equally improved irrespective of sex (CLI 17.5 % male vs. 20.0 % female; p = 0.681; need of subsequent EVR 21.1 % male vs. 21.9 % female; p = 0.844). Conclusions: Male sex was particularly associated with polyvascular disease, and CLI ratio was higher in female. However, primary technical success was high irrespective of sex. Despite some imbalances in cardiovascular risk factors and comorbidities, there is no difference in terms of technical success, periprocedural complications and clinical short-term outcome between male and female PAD patients at a tertiary vascular center.


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